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Characterization of H7N9 influenza A viruses isolated from humans

Author

Listed:
  • Tokiko Watanabe

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Maki Kiso

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Satoshi Fukuyama

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Noriko Nakajima

    (National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan)

  • Masaki Imai

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • Shinya Yamada

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Shin Murakami

    (International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Seiya Yamayoshi

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Kiyoko Iwatsuki-Horimoto

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Yoshihiro Sakoda

    (Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan)

  • Emi Takashita

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • Ryan McBride

    (The Scripps Research Institute, 10550 North Torrey Pines Road)

  • Takeshi Noda

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Masato Hatta

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Hirotaka Imai

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Dongming Zhao

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Noriko Kishida

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • Masayuki Shirakura

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • Robert P. de Vries

    (The Scripps Research Institute, 10550 North Torrey Pines Road)

  • Shintaro Shichinohe

    (Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan)

  • Masatoshi Okamatsu

    (Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan)

  • Tomokazu Tamura

    (Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan)

  • Yuriko Tomita

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Naomi Fujimoto

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Kazue Goto

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Hiroaki Katsura

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Eiryo Kawakami

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Izumi Ishikawa

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Shinji Watanabe

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan
    Laboratory of Veterinary Microbiology, University of Miyazaki, Miyazaki 889-2192, Japan)

  • Mutsumi Ito

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Yuko Sakai-Tagawa

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Yukihiko Sugita

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Ryuta Uraki

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Reina Yamaji

    (Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Amie J. Eisfeld

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Gongxun Zhong

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Shufang Fan

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Jihui Ping

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Eileen A. Maher

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Anthony Hanson

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Yuko Uchida

    (Influenza and Prion Disease Research Center, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan)

  • Takehiko Saito

    (Influenza and Prion Disease Research Center, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan)

  • Makoto Ozawa

    (Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
    Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan)

  • Gabriele Neumann

    (School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

  • Hiroshi Kida

    (Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan)

  • Takato Odagiri

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • James C. Paulson

    (The Scripps Research Institute, 10550 North Torrey Pines Road)

  • Hideki Hasegawa

    (National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan)

  • Masato Tashiro

    (Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan)

  • Yoshihiro Kawaoka

    (ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan
    Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA)

Abstract

Here, biological attributes of two early human isolates of the newly emerged H7N9 influenza viruses are characterized: the potential of these viruses to infect and/or transmit within various animal models is discussed, as is their relative sensitivity to neuraminidase inhibitors and experimental polymerase inhibitors compared to an H1N1 pandemic strain.

Suggested Citation

  • Tokiko Watanabe & Maki Kiso & Satoshi Fukuyama & Noriko Nakajima & Masaki Imai & Shinya Yamada & Shin Murakami & Seiya Yamayoshi & Kiyoko Iwatsuki-Horimoto & Yoshihiro Sakoda & Emi Takashita & Ryan Mc, 2013. "Characterization of H7N9 influenza A viruses isolated from humans," Nature, Nature, vol. 501(7468), pages 551-555, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7468:d:10.1038_nature12392
    DOI: 10.1038/nature12392
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    Cited by:

    1. Mansour Ebrahimi & Parisa Aghagolzadeh & Narges Shamabadi & Ahmad Tahmasebi & Mohammed Alsharifi & David L Adelson & Farhid Hemmatzadeh & Esmaeil Ebrahimie, 2014. "Understanding the Underlying Mechanism of HA-Subtyping in the Level of Physic-Chemical Characteristics of Protein," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-14, May.
    2. Tony Marion & Husni Elbahesh & Paul G Thomas & John P DeVincenzo & Richard Webby & Klaus Schughart, 2016. "Respiratory Mucosal Proteome Quantification in Human Influenza Infections," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-16, April.
    3. Juping Zhang & Yun Li & Zhen Jin & Huaiping Zhu, 2019. "Dynamics Analysis of an Avian Influenza A (H7N9) Epidemic Model with Vaccination and Seasonality," Complexity, Hindawi, vol. 2019, pages 1-15, March.

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