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Influence of tumour micro-environment heterogeneity on therapeutic response

Author

Listed:
  • Melissa R. Junttila

    (Genentech)

  • Frederic J. de Sauvage

    (Genentech)

Abstract

Tumour formation involves the co-evolution of neoplastic cells together with extracellular matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual metastasis is not determined solely by genetic alterations in tumour cells, but also by the fitness advantage such mutations confer in a given environment. As fitness is context dependent, evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount. The dynamic tumour topography varies drastically even throughout the same lesion. Heterologous cell types within tumours can actively influence therapeutic response and shape resistance.

Suggested Citation

  • Melissa R. Junttila & Frederic J. de Sauvage, 2013. "Influence of tumour micro-environment heterogeneity on therapeutic response," Nature, Nature, vol. 501(7467), pages 346-354, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12626
    DOI: 10.1038/nature12626
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    Cited by:

    1. Li Chen & Peter L Choyke & Niya Wang & Robert Clarke & Zaver M Bhujwalla & Elizabeth M C Hillman & Ge Wang & Yue Wang, 2014. "Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.
    2. Shiqian Ma & Daniel Johnson & Cody Ashby & Donghai Xiong & Carole L Cramer & Jason H Moore & Shuzhong Zhang & Xiuzhen Huang, 2015. "SPARCoC: A New Framework for Molecular Pattern Discovery and Cancer Gene Identification," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-19, March.
    3. Albert H Gough & Ning Chen & Tong Ying Shun & Timothy R Lezon & Robert C Boltz & Celeste E Reese & Jacob Wagner & Lawrence A Vernetti & Jennifer R Grandis & Adrian V Lee & Andrew M Stern & Mark E Schu, 2014. "Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-16, July.

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