IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v501y2013i7467d10.1038_nature12626.html
   My bibliography  Save this article

Influence of tumour micro-environment heterogeneity on therapeutic response

Author

Listed:
  • Melissa R. Junttila

    (Genentech)

  • Frederic J. de Sauvage

    (Genentech)

Abstract

Tumour formation involves the co-evolution of neoplastic cells together with extracellular matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual metastasis is not determined solely by genetic alterations in tumour cells, but also by the fitness advantage such mutations confer in a given environment. As fitness is context dependent, evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount. The dynamic tumour topography varies drastically even throughout the same lesion. Heterologous cell types within tumours can actively influence therapeutic response and shape resistance.

Suggested Citation

  • Melissa R. Junttila & Frederic J. de Sauvage, 2013. "Influence of tumour micro-environment heterogeneity on therapeutic response," Nature, Nature, vol. 501(7467), pages 346-354, September.
  • Handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12626
    DOI: 10.1038/nature12626
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12626
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature12626?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li Chen & Peter L Choyke & Niya Wang & Robert Clarke & Zaver M Bhujwalla & Elizabeth M C Hillman & Ge Wang & Yue Wang, 2014. "Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.
    2. Shiqian Ma & Daniel Johnson & Cody Ashby & Donghai Xiong & Carole L Cramer & Jason H Moore & Shuzhong Zhang & Xiuzhen Huang, 2015. "SPARCoC: A New Framework for Molecular Pattern Discovery and Cancer Gene Identification," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-19, March.
    3. Albert H Gough & Ning Chen & Tong Ying Shun & Timothy R Lezon & Robert C Boltz & Celeste E Reese & Jacob Wagner & Lawrence A Vernetti & Jennifer R Grandis & Adrian V Lee & Andrew M Stern & Mark E Schu, 2014. "Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-16, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12626. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.