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Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Author

Listed:
  • Greg M. Delgoffe

    (St Jude Children's Research Hospital)

  • Seng-Ryong Woo

    (St Jude Children's Research Hospital)

  • Meghan E. Turnis

    (St Jude Children's Research Hospital)

  • David M. Gravano

    (St Jude Children's Research Hospital)

  • Cliff Guy

    (St Jude Children's Research Hospital)

  • Abigail E. Overacre

    (St Jude Children's Research Hospital
    Integrated Biomedical Sciences Program, University of Tennessee Health Science Center)

  • Matthew L. Bettini

    (St Jude Children's Research Hospital)

  • Peter Vogel

    (St Jude Children's Research Hospital)

  • David Finkelstein

    (Computational Biology, St Jude Children's Research Hospital)

  • Jody Bonnevier

    (R&D Systems Inc.)

  • Creg J. Workman

    (St Jude Children's Research Hospital)

  • Dario A. A. Vignali

    (St Jude Children's Research Hospital)

Abstract

Neuropilin-1 (Nrp1) on regulatory T (Treg) cells is shown to interact with semaphorin-4a (Sema4a) to promote a program of Treg-cell stability and survival, in part through PTEN-mediated modulation of Akt signalling; Nrp1-deficient Treg cells can maintain immune homeostasis but fail to suppress in inflammatory sites, such as tumours, providing an attractive immunotherapeutic target for the treatment of cancers.

Suggested Citation

  • Greg M. Delgoffe & Seng-Ryong Woo & Meghan E. Turnis & David M. Gravano & Cliff Guy & Abigail E. Overacre & Matthew L. Bettini & Peter Vogel & David Finkelstein & Jody Bonnevier & Creg J. Workman & Da, 2013. "Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis," Nature, Nature, vol. 501(7466), pages 252-256, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7466:d:10.1038_nature12428
    DOI: 10.1038/nature12428
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    Cited by:

    1. Mike B. Barnkob & Yale S. Michaels & Violaine André & Philip S. Macklin & Uzi Gileadi & Salvatore Valvo & Margarida Rei & Corinna Kulicke & Ji-Li Chen & Vitul Jain & Victoria K. Woodcock & Huw Colin-Y, 2024. "Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Di Wu & Haomin Li & Mingwei Liu & Jun Qin & Yi Sun, 2022. "The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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