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Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Author

Listed:
  • Marcus Dorner

    (Center for the Study of Hepatitis C, The Rockefeller University
    Present addresses: Imperial College London, Department of Medicine, London W2 1NY, UK (M.D.); Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA (A.P.).)

  • Joshua A. Horwitz

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Bridget M. Donovan

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Rachael N. Labitt

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • William C. Budell

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Tamar Friling

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Alexander Vogt

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Maria Teresa Catanese

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Takashi Satoh

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Taro Kawai

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Shizuo Akira

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Mansun Law

    (The Scripps Research Institute)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Alexander Ploss

    (Center for the Study of Hepatitis C, The Rockefeller University
    Present addresses: Imperial College London, Department of Medicine, London W2 1NY, UK (M.D.); Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA (A.P.).)

Abstract

The entire hepatitis C virus life cycle can be recapitulated in an inbred mouse model, allowing preclinical assessment of antiviral therapeutics and vaccines.

Suggested Citation

  • Marcus Dorner & Joshua A. Horwitz & Bridget M. Donovan & Rachael N. Labitt & William C. Budell & Tamar Friling & Alexander Vogt & Maria Teresa Catanese & Takashi Satoh & Taro Kawai & Shizuo Akira & Ma, 2013. "Completion of the entire hepatitis C virus life cycle in genetically humanized mice," Nature, Nature, vol. 501(7466), pages 237-241, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7466:d:10.1038_nature12427
    DOI: 10.1038/nature12427
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