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Microbial colonization influences early B-lineage development in the gut lamina propria

Author

Listed:
  • Duane R. Wesemann

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA)

  • Andrew J. Portuguese

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Robin M. Meyers

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Michael P. Gallagher

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Kendra Cluff-Jones

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Jennifer M. Magee

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Rohit A. Panchakshari

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Scott J. Rodig

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA)

  • Thomas B. Kepler

    (Boston University School of Medicine, Boston, Massachusetts 02215, USA)

  • Frederick W. Alt

    (Children’s Hospital Boston, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

Abstract

Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon colonization of germ-free mice, and is thus influenced by commensal microbes.

Suggested Citation

  • Duane R. Wesemann & Andrew J. Portuguese & Robin M. Meyers & Michael P. Gallagher & Kendra Cluff-Jones & Jennifer M. Magee & Rohit A. Panchakshari & Scott J. Rodig & Thomas B. Kepler & Frederick W. Al, 2013. "Microbial colonization influences early B-lineage development in the gut lamina propria," Nature, Nature, vol. 501(7465), pages 112-115, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7465:d:10.1038_nature12496
    DOI: 10.1038/nature12496
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