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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

Author

Listed:
  • Tiziana Sonati

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Regina R. Reimann

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Jeppe Falsig

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Pravas Kumar Baral

    (Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada)

  • Tracy O’Connor

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Simone Hornemann

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Sine Yaganoglu

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Bei Li

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Uli S. Herrmann

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

  • Barbara Wieland

    (Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada)

  • Mridula Swayampakula

    (Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada)

  • Muhammad Hafizur Rahman

    (Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada)

  • Dipankar Das

    (Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada)

  • Nat Kav

    (Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada)

  • Roland Riek

    (ETH Zurich, Physical Chemistry, ETH Hönggerberg, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland)

  • Pawel P. Liberski

    (Laboratory of Electron Microscopy and Neuropathology, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland)

  • Michael N. G. James

    (Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada)

  • Adriano Aguzzi

    (Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland)

Abstract

Biochemical and structural investigation of a model for prion-induced neurodegeneration—antibody binding to PrPC—reveals the role of the PrP flexible tail and reactive oxygen species in mediating toxicity.

Suggested Citation

  • Tiziana Sonati & Regina R. Reimann & Jeppe Falsig & Pravas Kumar Baral & Tracy O’Connor & Simone Hornemann & Sine Yaganoglu & Bei Li & Uli S. Herrmann & Barbara Wieland & Mridula Swayampakula & Muhamm, 2013. "The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein," Nature, Nature, vol. 501(7465), pages 102-106, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7465:d:10.1038_nature12402
    DOI: 10.1038/nature12402
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    Cited by:

    1. Yan Zhang & Sergio Casas-Tinto & Diego E Rincon-Limas & Pedro Fernandez-Funez, 2014. "Combined Pharmacological Induction of Hsp70 Suppresses Prion Protein Neurotoxicity in Drosophila," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-10, February.

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