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Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

Author

Listed:
  • Tien Peng

    (Perelman School of Medicine at the University of Pennsylvania
    University of Pennsylvania)

  • Ying Tian

    (Perelman School of Medicine at the University of Pennsylvania
    Cardiovascular Institute, University of Pennsylvania)

  • Cornelis J. Boogerd

    (Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA)

  • Min Min Lu

    (Cardiovascular Institute, University of Pennsylvania)

  • Rachel S. Kadzik

    (Perelman School of Medicine at the University of Pennsylvania)

  • Kathleen M. Stewart

    (Perelman School of Medicine at the University of Pennsylvania
    Cardiovascular Institute, University of Pennsylvania)

  • Sylvia M. Evans

    (Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA)

  • Edward E. Morrisey

    (Perelman School of Medicine at the University of Pennsylvania
    Cardiovascular Institute, University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania
    Institute for Regenerative Medicine)

Abstract

A population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart expresses Wnt2, Gli1 and Isl1; these CPPs arise from cardiac progenitors before lung development, generate the mesoderm lineages within the cardiac inflow tract and lung, and are regulated by hedgehog expression from the foregut endoderm.

Suggested Citation

  • Tien Peng & Ying Tian & Cornelis J. Boogerd & Min Min Lu & Rachel S. Kadzik & Kathleen M. Stewart & Sylvia M. Evans & Edward E. Morrisey, 2013. "Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor," Nature, Nature, vol. 500(7464), pages 589-592, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12358
    DOI: 10.1038/nature12358
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    Cited by:

    1. Lu Han & Yongxia Wu & Kun Fang & Sean Sweeney & Ulyss K. Roesner & Melodie Parrish & Khushbu Patel & Tom Walter & Julia Piermattei & Anthony Trimboli & Julia Lefler & Cynthia D. Timmers & Xue-Zhong Yu, 2023. "The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Markus Draaken & Michael Knapp & Tracie Pennimpede & Johanna M Schmidt & Anne-Karolin Ebert & Wolfgang Rösch & Raimund Stein & Boris Utsch & Karin Hirsch & Thomas M Boemers & Elisabeth Mangold & Stefa, 2015. "Genome-wide Association Study and Meta-Analysis Identify ISL1 as Genome-wide Significant Susceptibility Gene for Bladder Exstrophy," PLOS Genetics, Public Library of Science, vol. 11(3), pages 1-13, March.
    3. Urban Lendahl & Lars Muhl & Christer Betsholtz, 2022. "Identification, discrimination and heterogeneity of fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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