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Avoiding chromosome pathology when replication forks collide

Author

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  • Christian J. Rudolph

    (Centre for Genetics and Genomics, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK
    School of Health Sciences and Social Care, Brunel University, Uxbridge, London UB8 3PH, UK)

  • Amy L. Upton

    (Centre for Genetics and Genomics, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK
    School of Health Sciences and Social Care, Brunel University, Uxbridge, London UB8 3PH, UK
    Present addresses: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK (A.L.U.); Division of Medicine, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK (A.S.).)

  • Anna Stockum

    (Centre for Genetics and Genomics, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK
    Present addresses: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK (A.L.U.); Division of Medicine, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK (A.S.).)

  • Conrad A. Nieduszynski

    (Centre for Genetics and Genomics, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK)

  • Robert G. Lloyd

    (Centre for Genetics and Genomics, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK)

Abstract

The site of collision between two chromosome replication forks can be used to reinitiate replication independent of an active origin, with potentially pathogenic effects.

Suggested Citation

  • Christian J. Rudolph & Amy L. Upton & Anna Stockum & Conrad A. Nieduszynski & Robert G. Lloyd, 2013. "Avoiding chromosome pathology when replication forks collide," Nature, Nature, vol. 500(7464), pages 608-611, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12312
    DOI: 10.1038/nature12312
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    Cited by:

    1. Dean Huang & Anna E. Johnson & Brandon S. Sim & Teresa W. Lo & Houra Merrikh & Paul A. Wiggins, 2023. "The in vivo measurement of replication fork velocity and pausing by lag-time analysis," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Alexander T. Duckworth & Peter L. Ducos & Sarah D. McMillan & Kenneth A. Satyshur & Katelien H. Blumenthal & Haley R. Deorio & Joseph A. Larson & Steven J. Sandler & Timothy Grant & James L. Keck, 2023. "Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Judith Oehler & Carl A. Morrow & Matthew C. Whitby, 2023. "Gene duplication and deletion caused by over-replication at a fork barrier," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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