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Charting a dynamic DNA methylation landscape of the human genome

Author

Listed:
  • Michael J. Ziller

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University)

  • Hongcang Gu

    (Broad Institute of MIT and Harvard)

  • Fabian Müller

    (Harvard University
    Present address: Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.)

  • Julie Donaghey

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University)

  • Linus T.-Y. Tsai

    (Beth Israel Deaconess Medical Center)

  • Oliver Kohlbacher

    (Applied Bioinformatics, Center for Bioinformatics and Quantitative Biology Center, University of Tübingen, 72074 Tübingen, Germany)

  • Philip L. De Jager

    (Broad Institute of MIT and Harvard
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, NRB168, Boston, Massachusetts 02115, USA)

  • Evan D. Rosen

    (Broad Institute of MIT and Harvard
    Beth Israel Deaconess Medical Center)

  • David A. Bennett

    (Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, Illinois 60612, USA)

  • Bradley E. Bernstein

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Andreas Gnirke

    (Broad Institute of MIT and Harvard)

  • Alexander Meissner

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University)

Abstract

Whole-genome bisulphite sequencing data from diverse human cell and tissue types shows that only about 22% of CpGs change their methylation state across these cell types; most of these CpGs are located at gene regulatory elements, particularly enhancers and transcription-factor-binding sites, and these selected regions with dynamic DNA methylation patterns could help to define putative regulatory elements further.

Suggested Citation

  • Michael J. Ziller & Hongcang Gu & Fabian Müller & Julie Donaghey & Linus T.-Y. Tsai & Oliver Kohlbacher & Philip L. De Jager & Evan D. Rosen & David A. Bennett & Bradley E. Bernstein & Andreas Gnirke , 2013. "Charting a dynamic DNA methylation landscape of the human genome," Nature, Nature, vol. 500(7463), pages 477-481, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7463:d:10.1038_nature12433
    DOI: 10.1038/nature12433
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    Cited by:

    1. Yanting Luo & Jianlin He & Xiguang Xu & Ming-an Sun & Xiaowei Wu & Xuemei Lu & Hehuang Xie, 2018. "Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-21, March.

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