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Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

Author

Listed:
  • Dhirendra K. Simanshu

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Ravi Kanth Kamlekar

    (Hormel Institute, University of Minnesota)

  • Dayanjan S. Wijesinghe

    (Virginia Commonwealth University)

  • Xianqiong Zou

    (Hormel Institute, University of Minnesota)

  • Xiuhong Zhai

    (Hormel Institute, University of Minnesota)

  • Shrawan K. Mishra

    (Hormel Institute, University of Minnesota)

  • Julian G. Molotkovsky

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences)

  • Lucy Malinina

    (Structural Biology Unit, CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio-Bilbao, Spain)

  • Edward H. Hinchcliffe

    (Hormel Institute, University of Minnesota)

  • Charles E. Chalfant

    (Virginia Commonwealth University
    Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia 23249
    Massey Cancer Center)

  • Rhoderick E. Brown

    (Hormel Institute, University of Minnesota)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

Abstract

A human lipid transfer protein (GLTPD1, named here CPTP) is shown to regulate eicosanoid production by mediating the intermembrane transfer of the phosphorylated sphingolipid ceramide-1-phosphate through a non-vesicular transport mechanism elucidated by structural, functional and biological data.

Suggested Citation

  • Dhirendra K. Simanshu & Ravi Kanth Kamlekar & Dayanjan S. Wijesinghe & Xianqiong Zou & Xiuhong Zhai & Shrawan K. Mishra & Julian G. Molotkovsky & Lucy Malinina & Edward H. Hinchcliffe & Charles E. Cha, 2013. "Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids," Nature, Nature, vol. 500(7463), pages 463-467, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7463:d:10.1038_nature12332
    DOI: 10.1038/nature12332
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    Cited by:

    1. Wan Ab Aziz Wan Daud* & Wong Kung Teck & Mohammad Taufiq Abdul Ghani, 2018. "A Conceptual Framework for Mobile Application in Learning Arabic Language Proficiency," The Journal of Social Sciences Research, Academic Research Publishing Group, pages 66-70:4.

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