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Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA

Author

Listed:
  • Jinwei Zhang

    (National Heart, Lung and Blood Institute, 50 South Drive, MSC 8012, Bethesda, Maryland 20892-8012, USA)

  • Adrian R. Ferré-D’Amaré

    (National Heart, Lung and Blood Institute, 50 South Drive, MSC 8012, Bethesda, Maryland 20892-8012, USA)

Abstract

The co-crystal structure of the T-box tRNA-binding region, stem I, bound to tRNA is solved, showing that this region not only binds the anticodon, but also cradles the entire tRNA, forming an extended interface; the two T-loop motifs of stem I mediate interactions similar to those of RNase P and the large ribosomal subunit, even though the three species do not share a common evolutionary ancestor.

Suggested Citation

  • Jinwei Zhang & Adrian R. Ferré-D’Amaré, 2013. "Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA," Nature, Nature, vol. 500(7462), pages 363-366, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7462:d:10.1038_nature12440
    DOI: 10.1038/nature12440
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    Cited by:

    1. Krishna C. Suddala & Janghyun Yoo & Lixin Fan & Xiaobing Zuo & Yun-Xing Wang & Hoi Sung Chung & Jinwei Zhang, 2023. "Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Eduardo Campos-Chavez & Sneha Paul & Zunwu Zhou & Dulce Alonso & Anjali R. Verma & Jingyi Fei & Alfonso Mondragón, 2024. "Translational T-box riboswitches bind tRNA by modulating conformational flexibility," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Xiaolin Niu & Zhonghe Xu & Yufan Zhang & Xiaobing Zuo & Chunlai Chen & Xianyang Fang, 2023. "Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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