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Epithelial junctions maintain tissue architecture by directing planar spindle orientation

Author

Listed:
  • Yu-ichiro Nakajima

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Emily J. Meyer

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Amanda Kroesen

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Sean A. McKinney

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Matthew C. Gibson

    (Stowers Institute for Medical Research, 1000 East 50th Street
    University of Kansas Medical Center, 3901 Rainbow Boulevard)

Abstract

The Drosophila tumour suppressors Scribbled and Discs large 1 are found to be essential regulators of planar spindle alignment during epithelial cell division; aberrant effects of spindle alignment are shown to be corrected through apoptosis, and the suppression of this mechanism can result in epithelial dysplasia and tumorigenesis.

Suggested Citation

  • Yu-ichiro Nakajima & Emily J. Meyer & Amanda Kroesen & Sean A. McKinney & Matthew C. Gibson, 2013. "Epithelial junctions maintain tissue architecture by directing planar spindle orientation," Nature, Nature, vol. 500(7462), pages 359-362, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7462:d:10.1038_nature12335
    DOI: 10.1038/nature12335
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    Cited by:

    1. Christophe Royer & Elizabeth Sandham & Elizabeth Slee & Falk Schneider & Christoffer B. Lagerholm & Jonathan Godwin & Nisha Veits & Holly Hathrell & Felix Zhou & Karolis Leonavicius & Jemma Garratt & , 2022. "ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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