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Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence

Author

Listed:
  • Aparna Venkatraman

    (Stowers Institute for Medical Research
    Centre for Stem Cell Research, Christian Medical College, Vellore 632002, India)

  • Xi C. He

    (Stowers Institute for Medical Research)

  • Joanne L. Thorvaldsen

    (University of Pennsylvania)

  • Ryohichi Sugimura

    (Stowers Institute for Medical Research)

  • John M. Perry

    (Stowers Institute for Medical Research)

  • Fang Tao

    (Stowers Institute for Medical Research)

  • Meng Zhao

    (Stowers Institute for Medical Research)

  • Matthew K. Christenson

    (Stowers Institute for Medical Research)

  • Rebeca Sanchez

    (Stowers Institute for Medical Research
    Cell Therapy and Genetics Laboratory, Institute de Recerca Vall d’hebron, Barcelona 08035, Spain)

  • Jaclyn Y. Yu

    (Stowers Institute for Medical Research)

  • Lai Peng

    (Toxicology & Therapeutics, University of Kansas Medical Center)

  • Jeffrey S. Haug

    (Stowers Institute for Medical Research)

  • Ariel Paulson

    (Stowers Institute for Medical Research)

  • Hua Li

    (Stowers Institute for Medical Research)

  • Xiao-bo Zhong

    (Toxicology & Therapeutics, University of Kansas Medical Center)

  • Thomas L. Clemens

    (Center for Musculoskeletal Research, Johns Hopkins Medicine)

  • Marisa S. Bartolomei

    (University of Pennsylvania)

  • Linheng Li

    (Stowers Institute for Medical Research
    University of Kansas Medical Center)

Abstract

Maternal genomic imprinting is crucial for the maintenance of adult stem cells, which is accomplished by maintaining long-term haematopoietic stem cell quiescence.

Suggested Citation

  • Aparna Venkatraman & Xi C. He & Joanne L. Thorvaldsen & Ryohichi Sugimura & John M. Perry & Fang Tao & Meng Zhao & Matthew K. Christenson & Rebeca Sanchez & Jaclyn Y. Yu & Lai Peng & Jeffrey S. Haug &, 2013. "Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence," Nature, Nature, vol. 500(7462), pages 345-349, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7462:d:10.1038_nature12303
    DOI: 10.1038/nature12303
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