IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v500y2013i7461d10.1038_nature12298.html
   My bibliography  Save this article

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

Author

Listed:
  • Karl R. Koehler

    (Medical Neuroscience Graduate Program, Indiana University School of Medicine
    Stark Neurosciences Research Institute, Indiana University School of Medicine
    Indiana University School of Medicine)

  • Andrew M. Mikosz

    (Stark Neurosciences Research Institute, Indiana University School of Medicine
    Indiana University School of Medicine)

  • Andrei I. Molosh

    (Stark Neurosciences Research Institute, Indiana University School of Medicine
    Indiana University School of Medicine)

  • Dharmeshkumar Patel

    (Stark Neurosciences Research Institute, Indiana University School of Medicine
    Indiana University School of Medicine)

  • Eri Hashino

    (Medical Neuroscience Graduate Program, Indiana University School of Medicine
    Stark Neurosciences Research Institute, Indiana University School of Medicine
    Indiana University School of Medicine)

Abstract

A new approach has been developed in order to achieve the stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells in a three-dimensional culture: this process, which mimics normal development and produces cells that have functional characteristics of mechanosensitive hair cells, is hoped to provide further insights into inner ear development and disorder.

Suggested Citation

  • Karl R. Koehler & Andrew M. Mikosz & Andrei I. Molosh & Dharmeshkumar Patel & Eri Hashino, 2013. "Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture," Nature, Nature, vol. 500(7461), pages 217-221, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12298
    DOI: 10.1038/nature12298
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12298
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12298?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jing Nie & Yoshitomo Ueda & Alexander J. Solivais & Eri Hashino, 2022. "CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12298. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.