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The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

Author

Listed:
  • Andrew Adey

    (University of Washington)

  • Joshua N. Burton

    (University of Washington)

  • Jacob O. Kitzman

    (University of Washington)

  • Joseph B. Hiatt

    (University of Washington)

  • Alexandra P. Lewis

    (University of Washington)

  • Beth K. Martin

    (University of Washington)

  • Ruolan Qiu

    (University of Washington)

  • Choli Lee

    (University of Washington)

  • Jay Shendure

    (University of Washington)

Abstract

Haplotype-resolved whole-genome sequencing of the HeLa CCL-2 strain shows that HeLa is relatively stable in terms of point variation; integration of several data sets reveals strong, haplotype-specific activation of the proto-oncogene MYC by the human papilloma virus type 18 genome, and enables the relationship between gene dosage and expression to be examined.

Suggested Citation

  • Andrew Adey & Joshua N. Burton & Jacob O. Kitzman & Joseph B. Hiatt & Alexandra P. Lewis & Beth K. Martin & Ruolan Qiu & Choli Lee & Jay Shendure, 2013. "The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line," Nature, Nature, vol. 500(7461), pages 207-211, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12064
    DOI: 10.1038/nature12064
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    Cited by:

    1. Xiaoli Wang & Wenlong Jia & Mengyao Wang & Jihong Liu & Xianrong Zhou & Zhiqing Liang & Qinghua Zhang & Sixiang Long & Suolang Quzhen & Xiangchun Li & Qiang Tian & Xiong Li & Haiying Sun & Caili Zhao , 2022. "Human papillomavirus integration perspective in small cell cervical carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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