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Restoration of anterior regeneration in a planarian with limited regenerative ability

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  • James M. Sikes

    (University of Illinois at Urbana-Champaign
    Present address: Department of Biology, University of San Francisco, San Francisco, California 94117, USA.)

  • Phillip A. Newmark

    (University of Illinois at Urbana-Champaign)

Abstract

Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; this study of Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, shows that Wnt signalling is aberrantly regulated in regeneration-deficient tissues and that downregulation of Wnt signalling in these regions restores regenerative abilities, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

Suggested Citation

  • James M. Sikes & Phillip A. Newmark, 2013. "Restoration of anterior regeneration in a planarian with limited regenerative ability," Nature, Nature, vol. 500(7460), pages 77-80, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12403
    DOI: 10.1038/nature12403
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