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Myc-driven endogenous cell competition in the early mammalian embryo

Author

Listed:
  • Cristina Clavería

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid E-28029, Spain)

  • Giovanna Giovinazzo

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid E-28029, Spain)

  • Rocío Sierra

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid E-28029, Spain)

  • Miguel Torres

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid E-28029, Spain)

Abstract

The epiblast is the mammalian embryonic tissue that contains the pluripotent stem cells that generate the whole embryo. We have established a method for inducing functional genetic mosaics in the mouse. Using this system, here we show that induction of a mosaic imbalance of Myc expression in the epiblast provokes the expansion of cells with higher Myc levels through the apoptotic elimination of cells with lower levels, without disrupting development. In contrast, homogeneous shifts in Myc levels did not affect epiblast cell viability, indicating that the observed competition results from comparison of relative Myc levels between epiblast cells. During normal development we found that Myc levels are intrinsically heterogeneous among epiblast cells, and that endogenous cell competition refines the epiblast cell population through the elimination of cells with low relative Myc levels. These results show that natural cell competition in the early mammalian embryo contributes to the selection of the epiblast cell pool.

Suggested Citation

  • Cristina Clavería & Giovanna Giovinazzo & Rocío Sierra & Miguel Torres, 2013. "Myc-driven endogenous cell competition in the early mammalian embryo," Nature, Nature, vol. 500(7460), pages 39-44, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12389
    DOI: 10.1038/nature12389
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    Cited by:

    1. Rachel Warren & Kylie Klinkhammer & Handeng Lyu & Joseph Knopp & Tingting Yuan & Changfu Yao & Barry Stripp & Stijn P. De Langhe, 2024. "Cell competition drives bronchiolization and pulmonary fibrosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Lin Li-Bao & Covadonga Díaz-Díaz & Morena Raiola & Rocío Sierra & Susana Temiño & Francisco J. Moya & Sandra Rodriguez-Perales & Elisa Santos & Giovanna Giovinazzo & Tore Bleckwehl & Álvaro Rada-Igles, 2024. "Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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