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Structural basis for the inhibition of bacterial multidrug exporters

Author

Listed:
  • Ryosuke Nakashima

    (Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan)

  • Keisuke Sakurai

    (Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan)

  • Seiji Yamasaki

    (Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan)

  • Katsuhiko Hayashi

    (Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan)

  • Chikahiro Nagata

    (Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan)

  • Kazuki Hoshino

    (Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan)

  • Yoshikuni Onodera

    (Daiichi Sankyo Co. Ltd, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan)

  • Kunihiko Nishino

    (Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan)

  • Akihito Yamaguchi

    (Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan)

Abstract

The first inhibitor-bound X-ray crystal structures of the bacterial multidrug efflux transporter AcrB and its homologue MexB are presented, with the inhibitor shown to bind the transporter through a narrow hydrophobic pit, thereby preventing rotation of AcrB and MexB monomers.

Suggested Citation

  • Ryosuke Nakashima & Keisuke Sakurai & Seiji Yamasaki & Katsuhiko Hayashi & Chikahiro Nagata & Kazuki Hoshino & Yoshikuni Onodera & Kunihiko Nishino & Akihito Yamaguchi, 2013. "Structural basis for the inhibition of bacterial multidrug exporters," Nature, Nature, vol. 500(7460), pages 102-106, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12300
    DOI: 10.1038/nature12300
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    Cited by:

    1. Jody L. Andersen & Gui-Xin He & Prathusha Kakarla & Ranjana KC & Sanath Kumar & Wazir Singh Lakra & Mun Mun Mukherjee & Indrika Ranaweera & Ugina Shrestha & Thuy Tran & Manuel F. Varela, 2015. "Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens," IJERPH, MDPI, vol. 12(2), pages 1-61, January.

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