IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v500y2013i7460d10.1038_nature12293.html
   My bibliography  Save this article

Reshaping of the conformational search of a protein by the chaperone trigger factor

Author

Listed:
  • Alireza Mashaghi

    (FOM institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands)

  • Günter Kramer

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, Heidelberg 69120, Germany)

  • Philipp Bechtluft

    (FOM institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands)

  • Beate Zachmann-Brand

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, Heidelberg 69120, Germany)

  • Arnold J. M. Driessen

    (Groningen Biomolecular Sciences and Biotechnology Institute and the Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9749 AG Groningen, The Netherlands)

  • Bernd Bukau

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, Heidelberg 69120, Germany)

  • Sander J. Tans

    (FOM institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands)

Abstract

The bacterial chaperone named trigger factor is found to stabilize protein folding intermediates that eventually convert to the native state, suggesting that chaperones play a direct role in instructing protein folding.

Suggested Citation

  • Alireza Mashaghi & Günter Kramer & Philipp Bechtluft & Beate Zachmann-Brand & Arnold J. M. Driessen & Bernd Bukau & Sander J. Tans, 2013. "Reshaping of the conformational search of a protein by the chaperone trigger factor," Nature, Nature, vol. 500(7460), pages 98-101, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12293
    DOI: 10.1038/nature12293
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12293
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12293?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12293. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.