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A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

Author

Listed:
  • Xiao-Jian Sun

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Zhanxin Wang

    (Structural Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center)

  • Lan Wang

    (Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
    Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA)

  • Yanwen Jiang

    (Weill Cornell Medical College, New York, New York 10065, USA)

  • Nils Kost

    (Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • T. David Soong

    (Institute for Computational Biomedicine, Weill Cornell Medical College)

  • Wei-Yi Chen

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Zhanyun Tang

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Tomoyoshi Nakadai

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Olivier Elemento

    (Institute for Computational Biomedicine, Weill Cornell Medical College)

  • Wolfgang Fischle

    (Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Ari Melnick

    (Weill Cornell Medical College, New York, New York 10065, USA)

  • Dinshaw J. Patel

    (Structural Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center)

  • Stephen D. Nimer

    (Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
    Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA)

  • Robert G. Roeder

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

Abstract

A multiprotein complex containing AML1–ETO, the most common fusion protein found in acute myeloid leukaemia, is revealed and analysed in leukaemic cells, and a novel, functionally important protein-binding interface is identified.

Suggested Citation

  • Xiao-Jian Sun & Zhanxin Wang & Lan Wang & Yanwen Jiang & Nils Kost & T. David Soong & Wei-Yi Chen & Zhanyun Tang & Tomoyoshi Nakadai & Olivier Elemento & Wolfgang Fischle & Ari Melnick & Dinshaw J. Pa, 2013. "A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis," Nature, Nature, vol. 500(7460), pages 93-97, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7460:d:10.1038_nature12287
    DOI: 10.1038/nature12287
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