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Biological features of novel avian influenza A (H7N9) virus

Author

Listed:
  • Jianfang Zhou

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Dayan Wang

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Rongbao Gao

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Baihui Zhao

    (Shanghai Municipal Disease Control and Prevention)

  • Jingdong Song

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Xian Qi

    (Jiangsu Provincial Disease Control and Prevention)

  • Yanjun Zhang

    (Zhejiang Provincial Disease Control and Prevention)

  • Yonglin Shi

    (Anhui Provincial Disease Control and Prevention)

  • Lei Yang

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Wenfei Zhu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Tian Bai

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Kun Qin

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Yu Lan

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Shumei Zou

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Junfeng Guo

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Jie Dong

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Libo Dong

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Ye Zhang

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Hejiang Wei

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Xiaodan Li

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Jian Lu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Liqi Liu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Xiang Zhao

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Xiyan Li

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Weijuan Huang

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Leying Wen

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Hong Bo

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Li Xin

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Yongkun Chen

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Cuilin Xu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Yuquan Pei

    (Key laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital)

  • Yue Yang

    (Key laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital)

  • Xiaodong Zhang

    (Key laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital)

  • Shiwen Wang

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Zijian Feng

    (Chinese Center for Disease Control and Prevention)

  • Jun Han

    (Chinese Center for Disease Control and Prevention)

  • Weizhong Yang

    (Chinese Center for Disease Control and Prevention)

  • George F. Gao

    (Chinese Center for Disease Control and Prevention)

  • Guizhen Wu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Dexin Li

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Yu Wang

    (Chinese Center for Disease Control and Prevention)

  • Yuelong Shu

    (National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

Abstract

An initial characterization of the receptor-binding properties of the novel avian influenza A (H7N9) shows that the virus has acquired the ability to bind human receptors while retaining the ability to bind avian receptors; the virus infects epithelial cells in the human lower respiratory tract and type II pneumocytes in the alveoli, and hypercytokinaemia was seen in infected patients.

Suggested Citation

  • Jianfang Zhou & Dayan Wang & Rongbao Gao & Baihui Zhao & Jingdong Song & Xian Qi & Yanjun Zhang & Yonglin Shi & Lei Yang & Wenfei Zhu & Tian Bai & Kun Qin & Yu Lan & Shumei Zou & Junfeng Guo & Jie Don, 2013. "Biological features of novel avian influenza A (H7N9) virus," Nature, Nature, vol. 499(7459), pages 500-503, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12379
    DOI: 10.1038/nature12379
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    Citations

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    Cited by:

    1. Qinling Yan & Sanyi Tang & Zhen Jin & Yanni Xiao, 2019. "Identifying Risk Factors Of A(H7N9) Outbreak by Wavelet Analysis and Generalized Estimating Equation," IJERPH, MDPI, vol. 16(8), pages 1-13, April.
    2. Manxue Jia & Hanjun Zhao & Nicholas C. Morano & Hong Lu & Yin-Ming Lui & Haijuan Du & Jordan E. Becker & Kwok-Yung Yuen & David D. Ho & Peter D. Kwong & Lawrence Shapiro & Kelvin Kai-Wang To & Xueling, 2024. "Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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