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Receptor binding by an H7N9 influenza virus from humans

Author

Listed:
  • Xiaoli Xiong

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Stephen R. Martin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Lesley F. Haire

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Stephen A. Wharton

    (WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Rodney S. Daniels

    (WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Michael S. Bennett

    (WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • John W. McCauley

    (WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Patrick J. Collins

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Philip A. Walker

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • John J. Skehel

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

  • Steven J. Gamblin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK)

Abstract

An examination of the receptor-binding properties of the H7N9 virus, which has recently emerged in China, shows that the virus has acquired the ability to bind the human α-2,6-linked sialic acid receptor while retaining binding to the avian α-2,3-linked receptor, and therefore does not have the preference for human versus avian receptors characteristic of pandemic viruses.

Suggested Citation

  • Xiaoli Xiong & Stephen R. Martin & Lesley F. Haire & Stephen A. Wharton & Rodney S. Daniels & Michael S. Bennett & John W. McCauley & Patrick J. Collins & Philip A. Walker & John J. Skehel & Steven J., 2013. "Receptor binding by an H7N9 influenza virus from humans," Nature, Nature, vol. 499(7459), pages 496-499, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12372
    DOI: 10.1038/nature12372
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