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Vascularized and functional human liver from an iPSC-derived organ bud transplant

Author

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  • Takanori Takebe

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
    Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan)

  • Keisuke Sekine

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Masahiro Enomura

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Hiroyuki Koike

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Masaki Kimura

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Takunori Ogaeri

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Ran-Ran Zhang

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Yasuharu Ueno

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Yun-Wen Zheng

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan)

  • Naoto Koike

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
    Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura, Chiba 285-8765, Japan)

  • Shinsuke Aoyama

    (ADME & Tox. Research Institute, Sekisui Medical Company Ltd., Tokai, Ibaraki 319-1182, Japan)

  • Yasuhisa Adachi

    (ADME & Tox. Research Institute, Sekisui Medical Company Ltd., Tokai, Ibaraki 319-1182, Japan)

  • Hideki Taniguchi

    (Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
    Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan)

Abstract

Vascularized, functional human liver is generated from human induced pluripotent stem cells (iPSCs) by transplantation of liver buds created in vitro (iPSC-LBs); hepatic cells self-organized into three-dimensional iPSC-LBs, and human vasculatures in iPSC-LB transplants became functional by connecting to host vessels, stimulating maturation of iPSC-LBs into tissue resembling adult liver and performing liver-specific functions.

Suggested Citation

  • Takanori Takebe & Keisuke Sekine & Masahiro Enomura & Hiroyuki Koike & Masaki Kimura & Takunori Ogaeri & Ran-Ran Zhang & Yasuharu Ueno & Yun-Wen Zheng & Naoto Koike & Shinsuke Aoyama & Yasuhisa Adachi, 2013. "Vascularized and functional human liver from an iPSC-derived organ bud transplant," Nature, Nature, vol. 499(7459), pages 481-484, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12271
    DOI: 10.1038/nature12271
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    Citations

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    Cited by:

    1. Sergei Grebenyuk & Abdel Rahman Abdel Fattah & Manoj Kumar & Burak Toprakhisar & Gregorius Rustandi & Anja Vananroye & Idris Salmon & Catherine Verfaillie & Mark Grillo & Adrian Ranga, 2023. "Large-scale perfused tissues via synthetic 3D soft microfluidics," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Erica Carolina & Yoshiki Kuse & Ayumu Okumura & Kenji Aoshima & Tomomi Tadokoro & Shinya Matsumoto & Eriko Kanai & Takashi Okumura & Toshiharu Kasai & Souichiro Yamabe & Yuji Nishikawa & Kiyoshi Yamag, 2024. "Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Francesca Lazzeri-Barcelo & Nuria Oliva-Vilarnau & Marion Baniol & Barbara Leibiger & Olaf Bergmann & Volker M. Lauschke & Ingo B. Leibiger & Noah Moruzzi & Per-Olof Berggren, 2024. "Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Bani Mukhopadhyay & Cheryl Marietta & Pei-Hong Shen & Abdul Oiseni & Faridoddin Mirshahi & Maria Mazzu & Colin Hodgkinson & Eli Winkler & Qiaoping Yuan & Daniel Miranda & George Kunos & Arun J. Sanyal, 2024. "A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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