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Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin

Author

Listed:
  • Jeongmin Song

    (Yale University School of Medicine)

  • Xiang Gao

    (Yale University School of Medicine)

  • Jorge E. Galán

    (Yale University School of Medicine)

Abstract

Unlike most salmonellae, Salmonella enterica serovar Typhi causes life-threatening systemic infections known as typhoid fever, for which the molecular basis is unknown; here administration of typhoid toxin produced by S. Typhi reproduces many of the acute symptoms of typhoid fever, carbohydrates on cell surface glycoproteins are identified as receptors for typhoid toxin and the toxin’s crystal structure is determined, providing insights into these interactions.

Suggested Citation

  • Jeongmin Song & Xiang Gao & Jorge E. Galán, 2013. "Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin," Nature, Nature, vol. 499(7458), pages 350-354, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7458:d:10.1038_nature12377
    DOI: 10.1038/nature12377
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    Cited by:

    1. Gi Young Lee & Jeongmin Song, 2024. "Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Lena Krone & Srujita Mahankali & Tobias Geiger, 2024. "Cytolysin A is an intracellularly induced and secreted cytotoxin of typhoidal Salmonella," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Han-Yi Chen & Wan-Chen Hsieh & Yu-Chieh Liu & Huei-Ying Li & Po-Yo Liu & Yu-Ting Hsu & Shao-Chun Hsu & An-Chi Luo & Wei-Chen Kuo & Yi-Jhen Huang & Gan-Guang Liou & Meng-Yun Lin & Chun-Jung Ko & Hsing-, 2024. "Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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