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PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

Author

Listed:
  • Lubin Jiang

    (Key Laboratory of Molecular Virology & Immunology, Unit of Human Parasite Molecular and Cell Biology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China)

  • Jianbing Mu

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Qingfeng Zhang

    (Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
    Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasite, F-75015 Paris, France
    CNRS, URA 2581, F-75015 Paris, France)

  • Ting Ni

    (State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University)

  • Prakash Srinivasan

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Kempaiah Rayavara

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Wenjing Yang

    (Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Louise Turner

    (Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark)

  • Thomas Lavstsen

    (Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark)

  • Thor G. Theander

    (Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark)

  • Weiqun Peng

    (George Washington University, 725 21st Street NW, Washington, DC 20052, USA)

  • Guiying Wei

    (Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine)

  • Qingqing Jing

    (Key Laboratory of Molecular Virology & Immunology, Unit of Human Parasite Molecular and Cell Biology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China)

  • Yoshiyuki Wakabayashi

    (Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Abhisheka Bansal

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Yan Luo

    (Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • José M. C. Ribeiro

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Artur Scherf

    (Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasite, F-75015 Paris, France
    CNRS, URA 2581, F-75015 Paris, France)

  • L. Aravind

    (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)

  • Jun Zhu

    (Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Keji Zhao

    (Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Louis H. Miller

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

The malaria parasite Plasmodium falciparum escapes immune detection by expressing one of 60 antigenically distinct var genes at any one time during the course of infection: here it is shown that the P. falciparum protein PfSETvs has a key role in var gene silencing through the trimethylation of histone H3K36.

Suggested Citation

  • Lubin Jiang & Jianbing Mu & Qingfeng Zhang & Ting Ni & Prakash Srinivasan & Kempaiah Rayavara & Wenjing Yang & Louise Turner & Thomas Lavstsen & Thor G. Theander & Weiqun Peng & Guiying Wei & Qingqing, 2013. "PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum," Nature, Nature, vol. 499(7457), pages 223-227, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12361
    DOI: 10.1038/nature12361
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    Cited by:

    1. Gayani Batugedara & Xueqing M. Lu & Borislav Hristov & Steven Abel & Zeinab Chahine & Thomas Hollin & Desiree Williams & Tina Wang & Anthony Cort & Todd Lenz & Trevor A. Thompson & Jacques Prudhomme &, 2023. "Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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