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Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

Author

Listed:
  • York Posor

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Marielle Eichhorn-Gruenig

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Dmytro Puchkov

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Johannes Schöneberg

    (Freie Universität Berlin, DFG Research Center MATHEON, Arnimallee 6, 14195 Berlin, Germany)

  • Alexander Ullrich

    (Freie Universität Berlin, DFG Research Center MATHEON, Arnimallee 6, 14195 Berlin, Germany)

  • André Lampe

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Rainer Müller

    (European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, 69117 Heidelberg, Germany)

  • Sirus Zarbakhsh

    (European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, 69117 Heidelberg, Germany)

  • Federico Gulluni

    (Molecular Biotechnology Center, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Torino, Italy)

  • Emilio Hirsch

    (Molecular Biotechnology Center, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Torino, Italy)

  • Michael Krauss

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Carsten Schultz

    (European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, 69117 Heidelberg, Germany)

  • Jan Schmoranzer

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany)

  • Frank Noé

    (Freie Universität Berlin, DFG Research Center MATHEON, Arnimallee 6, 14195 Berlin, Germany)

  • Volker Haucke

    (Leibniz Institut für Molekulare Pharmakologie (FMP) & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany
    Charite Universitätsmedizin, NeuroCure Cluster of Excellence, Chariteplatz 1, 10117 Berlin, Germany)

Abstract

Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.

Suggested Citation

  • York Posor & Marielle Eichhorn-Gruenig & Dmytro Puchkov & Johannes Schöneberg & Alexander Ullrich & André Lampe & Rainer Müller & Sirus Zarbakhsh & Federico Gulluni & Emilio Hirsch & Michael Krauss & , 2013. "Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate," Nature, Nature, vol. 499(7457), pages 233-237, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12360
    DOI: 10.1038/nature12360
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