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An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Author

Listed:
  • Sonia Sharma

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Ariel Quintana

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Gregory M. Findlay

    (Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Marcel Mettlen

    (The Scripps Research Institute)

  • Beate Baust

    (Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Mohit Jain

    (Broad Institute
    Brigham and Women’s Hospital)

  • Roland Nilsson

    (Karolinska Institute)

  • Anjana Rao

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Patrick G. Hogan

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

Abstract

A genome-wide RNA interference analysis identifies the septin family of cytoskeletal filaments as important regulators of store-operated Ca2+ entry into the cell; septins are shown to organize plasma membrane microdomains important in STIM1 and ORAI1 signalling, and may also be relevant in membrane microdomains underlying other signalling processes.

Suggested Citation

  • Sonia Sharma & Ariel Quintana & Gregory M. Findlay & Marcel Mettlen & Beate Baust & Mohit Jain & Roland Nilsson & Anjana Rao & Patrick G. Hogan, 2013. "An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry," Nature, Nature, vol. 499(7457), pages 238-242, July.
  • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12229
    DOI: 10.1038/nature12229
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