IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v499y2013i7457d10.1038_nature12229.html
   My bibliography  Save this article

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Author

Listed:
  • Sonia Sharma

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Ariel Quintana

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Gregory M. Findlay

    (Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Marcel Mettlen

    (The Scripps Research Institute)

  • Beate Baust

    (Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Mohit Jain

    (Broad Institute
    Brigham and Women’s Hospital)

  • Roland Nilsson

    (Karolinska Institute)

  • Anjana Rao

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

  • Patrick G. Hogan

    (La Jolla Institute for Allergy and Immunology
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School)

Abstract

A genome-wide RNA interference analysis identifies the septin family of cytoskeletal filaments as important regulators of store-operated Ca2+ entry into the cell; septins are shown to organize plasma membrane microdomains important in STIM1 and ORAI1 signalling, and may also be relevant in membrane microdomains underlying other signalling processes.

Suggested Citation

  • Sonia Sharma & Ariel Quintana & Gregory M. Findlay & Marcel Mettlen & Beate Baust & Mohit Jain & Roland Nilsson & Anjana Rao & Patrick G. Hogan, 2013. "An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry," Nature, Nature, vol. 499(7457), pages 238-242, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12229
    DOI: 10.1038/nature12229
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12229
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12229?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12229. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.