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Wnt activation in nail epithelium couples nail growth to digit regeneration

Author

Listed:
  • Makoto Takeo

    (New York University, School of Medicine)

  • Wei Chin Chou

    (New York University, School of Medicine)

  • Qi Sun

    (New York University, School of Medicine)

  • Wendy Lee

    (New York University, School of Medicine)

  • Piul Rabbani

    (New York University, School of Medicine)

  • Cynthia Loomis

    (New York University, School of Medicine)

  • M. Mark Taketo

    (Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan)

  • Mayumi Ito

    (New York University, School of Medicine)

Abstract

Nail stem cells (NSCs) reside in the proximal nail matrix, and early nail progenitors undergo Wnt-dependent differentiation into the nail; after amputation, Wnt activation is required for nail and digit regeneration, and amputations proximal to the Wnt-active nail progenitors fail to regenerate, but β-catenin stabilization in the NSC region induces regeneration.

Suggested Citation

  • Makoto Takeo & Wei Chin Chou & Qi Sun & Wendy Lee & Piul Rabbani & Cynthia Loomis & M. Mark Taketo & Mayumi Ito, 2013. "Wnt activation in nail epithelium couples nail growth to digit regeneration," Nature, Nature, vol. 499(7457), pages 228-232, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12214
    DOI: 10.1038/nature12214
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