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High-resolution analysis with novel cell-surface markers identifies routes to iPS cells

Author

Listed:
  • James O’Malley

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

  • Stavroula Skylaki

    (Stem Cell Dynamics Research Unit, Helmholtz Center Munich, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany)

  • Kumiko A. Iwabuchi

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

  • Eleni Chantzoura

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

  • Tyson Ruetz

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

  • Anna Johnsson

    (Laboratory for Molecular Neurobiology, Karolinska Institute, Scheeles väg 1, SE-171 77 Stockholm, Sweden)

  • Simon R. Tomlinson

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

  • Sten Linnarsson

    (Laboratory for Molecular Neurobiology, Karolinska Institute, Scheeles väg 1, SE-171 77 Stockholm, Sweden)

  • Keisuke Kaji

    (MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK)

Abstract

Cellular reprogramming is shown to occur in an ordered, stepwise manner, marked by changes in the cell-surface markers CD44, ICAM1 and Nanog–eGFP; molecular characterization of discrete subpopulations of partially reprogrammed cells shows that reprogramming is not simply the reversal of the normal development process.

Suggested Citation

  • James O’Malley & Stavroula Skylaki & Kumiko A. Iwabuchi & Eleni Chantzoura & Tyson Ruetz & Anna Johnsson & Simon R. Tomlinson & Sten Linnarsson & Keisuke Kaji, 2013. "High-resolution analysis with novel cell-surface markers identifies routes to iPS cells," Nature, Nature, vol. 499(7456), pages 88-91, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7456:d:10.1038_nature12243
    DOI: 10.1038/nature12243
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