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Variation and genetic control of protein abundance in humans

Author

Listed:
  • Linfeng Wu

    (Stanford University School of Medicine)

  • Sophie I. Candille

    (Stanford University School of Medicine)

  • Yoonha Choi

    (Stanford University School of Medicine)

  • Dan Xie

    (Stanford University School of Medicine)

  • Lihua Jiang

    (Stanford University School of Medicine)

  • Jennifer Li-Pook-Than

    (Stanford University School of Medicine)

  • Hua Tang

    (Stanford University School of Medicine)

  • Michael Snyder

    (Stanford University School of Medicine)

Abstract

A large-scale analysis of variation in human protein levels between individuals is performed using mass-spectrometry-based proteomic technology, and a number of protein quantitative trait loci are identified; over 5% of proteins vary by more than 1.5-fold in their expression levels between individuals, and this variation is not always linked to RNA level.

Suggested Citation

  • Linfeng Wu & Sophie I. Candille & Yoonha Choi & Dan Xie & Lihua Jiang & Jennifer Li-Pook-Than & Hua Tang & Michael Snyder, 2013. "Variation and genetic control of protein abundance in humans," Nature, Nature, vol. 499(7456), pages 79-82, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7456:d:10.1038_nature12223
    DOI: 10.1038/nature12223
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    Cited by:

    1. Isabelle Rose Leo & Luay Aswad & Matthias Stahl & Elena Kunold & Frederik Post & Tom Erkers & Nona Struyf & Georgios Mermelekas & Rubin Narayan Joshi & Eva Gracia-Villacampa & Päivi Östling & Olli P. , 2022. "Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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