IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v499y2013i7456d10.1038_nature12215.html
   My bibliography  Save this article

ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

Author

Listed:
  • Lingbo Zhang

    (Massachusetts Institute of Technology
    Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, 117576 Singapore
    Stem Cell and Developmental Biology, Genome Institute of Singapore, A*STAR, 138627 Singapore)

  • Lina Prak

    (Massachusetts Institute of Technology)

  • Violeta Rayon-Estrada

    (Massachusetts Institute of Technology
    Present addresses: Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 22184 Lund, Sweden (J.F.); The Rockefeller University, New York, New York 10065, USA (V.R.-E.).)

  • Prathapan Thiru

    (Massachusetts Institute of Technology)

  • Johan Flygare

    (Massachusetts Institute of Technology
    Present addresses: Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 22184 Lund, Sweden (J.F.); The Rockefeller University, New York, New York 10065, USA (V.R.-E.).)

  • Bing Lim

    (Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, 117576 Singapore
    Stem Cell and Developmental Biology, Genome Institute of Singapore, A*STAR, 138627 Singapore
    Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Harvey F. Lodish

    (Massachusetts Institute of Technology
    Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, 117576 Singapore)

Abstract

Under stress conditions such as acute blood loss or chronic anaemia, glucocorticoids trigger self-renewal of early burst-forming unit–erythroid (BFU–E) progenitors in the spleen, however, the mechanism of glucocorticoid action is not well understood; here the RNA binding protein ZFP36L2 is identified as a transcriptional target of the glucocorticoid receptor in BFU-Es and is shown to be involved in the process of erythroid cell expansion following exposure to glucocorticoids.

Suggested Citation

  • Lingbo Zhang & Lina Prak & Violeta Rayon-Estrada & Prathapan Thiru & Johan Flygare & Bing Lim & Harvey F. Lodish, 2013. "ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors," Nature, Nature, vol. 499(7456), pages 92-96, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7456:d:10.1038_nature12215
    DOI: 10.1038/nature12215
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12215
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12215?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:499:y:2013:i:7456:d:10.1038_nature12215. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.