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Combinatorial temporal patterning in progenitors expands neural diversity

Author

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  • Omer Ali Bayraktar

    (Howard Hughes Medical Institute, University of Oregon
    Institute of Molecular Biology, University of Oregon)

  • Chris Q. Doe

    (Howard Hughes Medical Institute, University of Oregon
    Institute of Molecular Biology, University of Oregon
    Institute of Neuroscience, University of Oregon)

Abstract

Human outer subventricular zone (OSVZ) neural progenitors and Drosophila type II neuroblasts both generate intermediate neural progenitors (INPs) that populate the adult cerebral cortex or central complex, respectively. It is unknown whether INPs simply expand or also diversify neural cell types. Here we show that Drosophila INPs sequentially generate distinct neural subtypes, that INPs sequentially express Dichaete, Grainy head and Eyeless transcription factors, and that these transcription factors are required for the production of distinct neural subtypes. Moreover, parental type II neuroblasts also sequentially express transcription factors and generate different neuronal/glial progeny over time, providing a second temporal identity axis. We conclude that neuroblast and INP temporal patterning axes act together to generate increased neural diversity within the adult central complex; OSVZ progenitors may use similar mechanisms to increase neural diversity in the human brain.

Suggested Citation

  • Omer Ali Bayraktar & Chris Q. Doe, 2013. "Combinatorial temporal patterning in progenitors expands neural diversity," Nature, Nature, vol. 498(7455), pages 449-455, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12266
    DOI: 10.1038/nature12266
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    Cited by:

    1. Hailun Zhu & Sihai Dave Zhao & Alokananda Ray & Yu Zhang & Xin Li, 2022. "A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Bert I. Crawford & Mary Jo Talley & Joshua Russman & James Riddle & Sabrina Torres & Troy Williams & Michelle S. Longworth, 2024. "Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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