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Severe malaria is associated with parasite binding to endothelial protein C receptor

Author

Listed:
  • Louise Turner

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Thomas Lavstsen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Sanne S. Berger

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Christian W. Wang

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Jens E. V. Petersen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Marion Avril

    (Seattle Biomedical Research Institute)

  • Andrew J. Brazier

    (Seattle Biomedical Research Institute)

  • Jim Freeth

    (Retrogenix, Crown House, Bingswood Estate, Whaley Bridge, High Peak SK23 7LY, UK)

  • Jakob S. Jespersen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Morten A. Nielsen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Pamela Magistrado

    (National Institute of Medical Research, Tanga Centre, Tanga, Tanzania)

  • John Lusingu

    (National Institute of Medical Research, Tanga Centre, Tanga, Tanzania)

  • Joseph D. Smith

    (Seattle Biomedical Research Institute
    University of Washington)

  • Matthew K. Higgins

    (University of Oxford, South Parks Road, Oxford OX1 3QU, UK)

  • Thor G. Theander

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

Abstract

Endothelial protein C receptor is shown to be the receptor for Plasmodium falciparum erythrocyte membrane protein 1 variants associated with severe malaria.

Suggested Citation

  • Louise Turner & Thomas Lavstsen & Sanne S. Berger & Christian W. Wang & Jens E. V. Petersen & Marion Avril & Andrew J. Brazier & Jim Freeth & Jakob S. Jespersen & Morten A. Nielsen & Pamela Magistrado, 2013. "Severe malaria is associated with parasite binding to endothelial protein C receptor," Nature, Nature, vol. 498(7455), pages 502-505, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12216
    DOI: 10.1038/nature12216
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    Cited by:

    1. Gerry Q Tonkin-Hill & Leily Trianty & Rintis Noviyanti & Hanh H T Nguyen & Boni F Sebayang & Daniel A Lampah & Jutta Marfurt & Simon A Cobbold & Janavi S Rambhatla & Malcolm J McConville & Stephen J R, 2018. "The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes," PLOS Biology, Public Library of Science, vol. 16(3), pages 1-40, March.
    2. Timothy F. Shay & Seongmin Jang & Tyler J. Brittain & Xinhong Chen & Beth Walker & Claire Tebbutt & Yujie Fan & Damien A. Wolfe & Cynthia M. Arokiaraj & Erin E. Sullivan & Xiaozhe Ding & Ting-Yu Wang , 2024. "Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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