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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Author

Listed:
  • Michael T. Y. Lam

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Han Cho

    (Salk Institute for Biological Studies, 10010 North Torrey Pines Road)

  • Hanna P. Lesch

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • David Gosselin

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Sven Heinz

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Yumiko Tanaka-Oishi

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Christopher Benner

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Minna U. Kaikkonen

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Aneeza S. Kim

    (Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA)

  • Mika Kosaka

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Cindy Y. Lee

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Andy Watt

    (Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA)

  • Tamar R. Grossman

    (Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA)

  • Michael G. Rosenfeld

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Howard Hughes Medical Institute, 4000 Jones Bridge Road)

  • Ronald M. Evans

    (Salk Institute for Biological Studies, 10010 North Torrey Pines Road
    Howard Hughes Medical Institute, 4000 Jones Bridge Road)

  • Christopher K. Glass

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

Abstract

It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, the repressive functions of Rev-Erb nuclear receptors in macrophages are shown to be linked to their ability to inhibit the transcription of eRNAs.

Suggested Citation

  • Michael T. Y. Lam & Han Cho & Hanna P. Lesch & David Gosselin & Sven Heinz & Yumiko Tanaka-Oishi & Christopher Benner & Minna U. Kaikkonen & Aneeza S. Kim & Mika Kosaka & Cindy Y. Lee & Andy Watt & Ta, 2013. "Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription," Nature, Nature, vol. 498(7455), pages 511-515, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12209
    DOI: 10.1038/nature12209
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