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HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

Author

Listed:
  • Arik Cooper

    (Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA)

  • Mayra García

    (Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA)

  • Constantinos Petrovas

    (Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA)

  • Takuya Yamamoto

    (Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA)

  • Richard A. Koup

    (Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA)

  • Gary J. Nabel

    (Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA
    Present address: Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, USA.)

Abstract

HIV-1 causes CD4+T-cell death through viral integration by stimulation of DNA-dependent protein kinase (DNA-PK), a protein known to act in the p53 damage response pathway for double-stranded DNA breaks, in activated cells.

Suggested Citation

  • Arik Cooper & Mayra García & Constantinos Petrovas & Takuya Yamamoto & Richard A. Koup & Gary J. Nabel, 2013. "HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration," Nature, Nature, vol. 498(7454), pages 376-379, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7454:d:10.1038_nature12274
    DOI: 10.1038/nature12274
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    Cited by:

    1. Abraham J. Arenas & Gilberto González-Parra & Jhon J. Naranjo & Myladis Cogollo & Nicolás De La Espriella, 2021. "Mathematical Analysis and Numerical Solution of a Model of HIV with a Discrete Time Delay," Mathematics, MDPI, vol. 9(3), pages 1-21, January.
    2. Farina Karim & Catherine Riou & Mallory Bernstein & Zesuliwe Jule & Gila Lustig & Strauss Graan & Roanne S. Keeton & Janine-Lee Upton & Yashica Ganga & Khadija Khan & Kajal Reedoy & Matilda Mazibuko &, 2024. "Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Khadija Leena & Mafiun Nafisa Huq & Rabeya Ahmed & Abdullah Enam & Probal Kumar Mondal & Afsana Anwar & Abu Ansar Md. Rizwan (Corresponding author), 2022. "Management of HIV positive patients by direct approach from dental service providers of Bangladesh," International Journal of Science and Business, IJSAB International, vol. 10(1), pages 123-129.

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