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Vector transmission regulates immune control of Plasmodium virulence

Author

Listed:
  • Philip J. Spence

    (MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK)

  • William Jarra

    (MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK)

  • Prisca Lévy

    (MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK)

  • Adam J. Reid

    (Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Lia Chappell

    (Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Thibaut Brugat

    (MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK)

  • Mandy Sanders

    (Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Matthew Berriman

    (Parasite Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Jean Langhorne

    (MRC National Institute for Medical Research (NIMR), Mill Hill, London NW7 1AA, UK)

Abstract

Serial passage of the malaria parasite through rodents, primates or human hosts increases parasite virulence, suggesting that vector transmission regulates virulence, although direct evidence for this has been lacking; mosquito transmission is shown here to intrinsically modify asexual blood-stage Plasmodium chabaudi chabaudi, which elicits altered host immune responses that, in turn, modify disease severity.

Suggested Citation

  • Philip J. Spence & William Jarra & Prisca Lévy & Adam J. Reid & Lia Chappell & Thibaut Brugat & Mandy Sanders & Matthew Berriman & Jean Langhorne, 2013. "Vector transmission regulates immune control of Plasmodium virulence," Nature, Nature, vol. 498(7453), pages 228-231, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7453:d:10.1038_nature12231
    DOI: 10.1038/nature12231
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