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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

Author

Listed:
  • John R. Lukens

    (St Jude Children’s Research Hospital)

  • Peter Vogel

    (Animal Resources Center and the Veterinary Pathology Core, St Jude Children’s Research Hospital)

  • Gordon R. Johnson

    (St Jude Children’s Research Hospital)

  • Michelle A. Kelliher

    (University of Massachusetts Medical School)

  • Yoichiro Iwakura

    (Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)

  • Mohamed Lamkanfi

    (VIB, B-9000 Ghent, Belgium
    Ghent University, B-9000 Ghent, Belgium)

  • Thirumala-Devi Kanneganti

    (St Jude Children’s Research Hospital)

Abstract

This study defines a novel RIP1-kinase- and IL-1α-dependent autoinflammatory pathway that depends on NF-κB and is controlled by the tyrosine phosphatase SHP-1.

Suggested Citation

  • John R. Lukens & Peter Vogel & Gordon R. Johnson & Michelle A. Kelliher & Yoichiro Iwakura & Mohamed Lamkanfi & Thirumala-Devi Kanneganti, 2013. "RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3," Nature, Nature, vol. 498(7453), pages 224-227, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7453:d:10.1038_nature12174
    DOI: 10.1038/nature12174
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