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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

Author

Listed:
  • Scott R. Floyd

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Beth Israel Deaconess Medical Center)

  • Michael E. Pacold

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Dana-Farber Cancer Institute
    Whitehead Institute)

  • Qiuying Huang

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Scott M. Clarke

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Fred C. Lam

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Ian G. Cannell

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Bryan D. Bryson

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Jonathan Rameseder

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Michael J. Lee

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Emily J. Blake

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Anna Fydrych

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Richard Ho

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Benjamin A. Greenberger

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Grace C. Chen

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Amanda Maffa

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Amanda M. Del Rosario

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • David E. Root

    (Broad Institute of Harvard and MIT)

  • Anne E. Carpenter

    (Broad Institute of Harvard and MIT)

  • William C. Hahn

    (Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute)

  • David M. Sabatini

    (Whitehead Institute
    Broad Institute of Harvard and MIT)

  • Clark C. Chen

    (Dana-Farber Cancer Institute
    Beth Israel Deaconess Medical Center)

  • Forest M. White

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • James E. Bradner

    (Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute)

  • Michael B. Yaffe

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT
    Beth Israel Deaconess Medical Center
    Massachusetts Institute of Technology)

Abstract

Isoform B of the chromatin-binding protein Brd4 acts to suppress DNA damage response signalling.

Suggested Citation

  • Scott R. Floyd & Michael E. Pacold & Qiuying Huang & Scott M. Clarke & Fred C. Lam & Ian G. Cannell & Bryan D. Bryson & Jonathan Rameseder & Michael J. Lee & Emily J. Blake & Anna Fydrych & Richard Ho, 2013. "The bromodomain protein Brd4 insulates chromatin from DNA damage signalling," Nature, Nature, vol. 498(7453), pages 246-250, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7453:d:10.1038_nature12147
    DOI: 10.1038/nature12147
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    Citations

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    Cited by:

    1. John K. Barrows & Baicheng Lin & Colleen E. Quaas & George Fullbright & Elizabeth N. Wallace & David T. Long, 2022. "BRD4 promotes resection and homology-directed repair of DNA double-strand breaks," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Nathaniel G. Jones & Vincent Geoghegan & Gareth Moore & Juliana B. T. Carnielli & Katherine Newling & Félix Calderón & Raquel Gabarró & Julio Martín & Rab K. Prinjha & Inmaculada Rioja & Anthony J. Wi, 2022. "Bromodomain factor 5 is an essential regulator of transcription in Leishmania," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Annkatrin Bressin & Olga Jasnovidova & Mirjam Arnold & Elisabeth Altendorfer & Filip Trajkovski & Thomas A. Kratz & Joanna E. Handzlik & Denes Hnisz & Andreas Mayer, 2023. "High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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