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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Author

Listed:
  • Matthew R. Hepworth

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Laurel A. Monticelli

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Thomas C. Fung

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Carly G. K. Ziegler

    (ImmunoDynamics Group, Programs in Computational Biology and Immunology, Memorial Sloan-Kettering Cancer Center)

  • Stephanie Grunberg

    (Perelman School of Medicine, University of Pennsylvania)

  • Rohini Sinha

    (Perelman School of Medicine, University of Pennsylvania)

  • Adriana R. Mantegazza

    (Perelman School of Medicine, University of Pennsylvania)

  • Hak-Ling Ma

    (Inflammation and Immunology Research Unit, Biotherapeutics Research and Development, Pfizer Worldwide R&D, Cambridge, Massachusetts 02140, USA)

  • Alison Crawford

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Jill M. Angelosanto

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • E. John Wherry

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Pandelakis A. Koni

    (Cancer Immunology, Inflammation & Tolerance Program, Georgia Health Sciences University Cancer Center)

  • Frederic D. Bushman

    (Perelman School of Medicine, University of Pennsylvania)

  • Charles O. Elson

    (University of Alabama at Birmingham)

  • Gérard Eberl

    (Lymphoid Tissue Development Unit, Institute Pasteur, 75724 Paris, France
    Centre National de la Recherche Scientifique, URA 1961, 75724 Paris, France)

  • David Artis

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

  • Gregory F. Sonnenberg

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

Abstract

Group 3 innate lymphoid cells are shown to process and present antigen and to control CD4+ T-cell responses to intestinal commensal bacteria through an MHC-class-II-dependent mechanism.

Suggested Citation

  • Matthew R. Hepworth & Laurel A. Monticelli & Thomas C. Fung & Carly G. K. Ziegler & Stephanie Grunberg & Rohini Sinha & Adriana R. Mantegazza & Hak-Ling Ma & Alison Crawford & Jill M. Angelosanto & E., 2013. "Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria," Nature, Nature, vol. 498(7452), pages 113-117, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12240
    DOI: 10.1038/nature12240
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    Cited by:

    1. Jiacheng Hao & Chang Liu & Zhijie Gu & Xuanming Yang & Xun Lan & Xiaohuan Guo, 2024. "Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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