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Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

Author

Listed:
  • Jungwook Kim

    (Albert Einstein College of Medicine)

  • Hui Xiao

    (Albert Einstein College of Medicine)

  • Jeffrey B. Bonanno

    (Albert Einstein College of Medicine)

  • Chakrapani Kalyanaraman

    (University of California at San Francisco)

  • Shoshana Brown

    (University of California at San Francisco)

  • Xiangying Tang

    (Albert Einstein College of Medicine)

  • Nawar F. Al-Obaidi

    (Albert Einstein College of Medicine)

  • Yury Patskovsky

    (Albert Einstein College of Medicine)

  • Patricia C. Babbitt

    (University of California at San Francisco)

  • Matthew P. Jacobson

    (University of California at San Francisco)

  • Young-Sam Lee

    (Johns Hopkins University)

  • Steven C. Almo

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

Abstract

Members of the SAM-dependent methyltransferase superfamily are involved in the modification of wobble uridine to 5-oxacetyl uridine in Gram-negative bacteria; CmoA converts SAM to carboxy-SAM (Cx-SAM; a metabolite that was unknown previously), and CmoB uses Cx-SAM to convert 5-hydroxyuridine to 5-oxyacetyl uridine in tRNA.

Suggested Citation

  • Jungwook Kim & Hui Xiao & Jeffrey B. Bonanno & Chakrapani Kalyanaraman & Shoshana Brown & Xiangying Tang & Nawar F. Al-Obaidi & Yury Patskovsky & Patricia C. Babbitt & Matthew P. Jacobson & Young-Sam , 2013. "Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function," Nature, Nature, vol. 498(7452), pages 123-126, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12180
    DOI: 10.1038/nature12180
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    Cited by:

    1. Nikos Pinotsis & Anna Krüger & Nicolas Tomas & Spyros D. Chatziefthymiou & Claudia Litz & Simon Arnold Mortensen & Mamadou Daffé & Hedia Marrakchi & Garabed Antranikian & Matthias Wilmanns, 2023. "Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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