IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v498y2013i7452d10.1038_nature12166.html
   My bibliography  Save this article

Control of angiogenesis by AIBP-mediated cholesterol efflux

Author

Listed:
  • Longhou Fang

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Soo-Ho Choi

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Ji Sun Baek

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Chao Liu

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Felicidad Almazan

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Florian Ulrich

    (Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, 540 First Avenue, New York, New York 10016, USA)

  • Philipp Wiesner

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Adam Taleb

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Elena Deer

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Jennifer Pattison

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Jesús Torres-Vázquez

    (Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, 540 First Avenue, New York, New York 10016, USA)

  • Andrew C. Li

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Yury I. Miller

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

Abstract

Gene-expression studies are used to elucidate the relationship between cholesterol regulation and angiogenesis: apolipoprotein A-1 binding protein (AIBP) is found to enhance cholesterol influx from endothelial cells to high-density lipoprotein, and the resulting cholesterol depletion alters membrane lipid order in the vasculature, leading to decreased vascular endothelial growth factor receptor signalling.

Suggested Citation

  • Longhou Fang & Soo-Ho Choi & Ji Sun Baek & Chao Liu & Felicidad Almazan & Florian Ulrich & Philipp Wiesner & Adam Taleb & Elena Deer & Jennifer Pattison & Jesús Torres-Vázquez & Andrew C. Li & Yury I., 2013. "Control of angiogenesis by AIBP-mediated cholesterol efflux," Nature, Nature, vol. 498(7452), pages 118-122, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12166
    DOI: 10.1038/nature12166
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12166
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12166?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12166. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.