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Breen et al. reply

Author

Listed:
  • Michael S. Breen

    (University of California San Diego)

  • Carsten Kemena

    (†Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
    ‡Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Peter K. Vlasov

    (†Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
    ‡Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Cedric Notredame

    (†Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
    ‡Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Fyodor A. Kondrashov

    (†Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain
    ‡Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
    §Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluís Companys, 08010 Barcelona, Spain)

Abstract

replying to D. M. McCandlish, E. Rajon, P. Shah, Y. Ding & J. B. Plotkin Nature 497, 10.1038/nature12219 (2013) Understanding fitness landscapes, a conceptual depiction of the genotype-to-phenotype relationship, is crucial to many areas of biology. Two aspects of fitness landscapes are the focus of contemporary studies of molecular evolution. First, the local shape of the fitness landscape defined by the contribution of individual alleles to fitness that is independent of all genetic interactions. Second, the global, multidimensional fitness landscape1 shape determined by how interactions between alleles at different loci change each other’s fitness impact, or epistasis. In explaining the high amino-acid usage (u), we focused on the global shape of the fitness landscape2, ignoring the perturbations at individual sites3.

Suggested Citation

  • Michael S. Breen & Carsten Kemena & Peter K. Vlasov & Cedric Notredame & Fyodor A. Kondrashov, 2013. "Breen et al. reply," Nature, Nature, vol. 497(7451), pages 2-3, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7451:d:10.1038_nature12220
    DOI: 10.1038/nature12220
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