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BAF complexes facilitate decatenation of DNA by topoisomerase IIα

Author

Listed:
  • Emily C. Dykhuizen

    (Howard Hughes Medical Institute, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Diana C. Hargreaves

    (Howard Hughes Medical Institute, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Erik L. Miller

    (Howard Hughes Medical Institute, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Kairong Cui

    (National Institutes of Health)

  • Andrey Korshunov

    (CCU Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany)

  • Marcel Kool

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany)

  • Stefan Pfister

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg 69120, Germany)

  • Yoon-Jae Cho

    (Stanford University Medical School)

  • Keji Zhao

    (National Institutes of Health)

  • Gerald R. Crabtree

    (Howard Hughes Medical Institute, Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M arrest.

Suggested Citation

  • Emily C. Dykhuizen & Diana C. Hargreaves & Erik L. Miller & Kairong Cui & Andrey Korshunov & Marcel Kool & Stefan Pfister & Yoon-Jae Cho & Keji Zhao & Gerald R. Crabtree, 2013. "BAF complexes facilitate decatenation of DNA by topoisomerase IIα," Nature, Nature, vol. 497(7451), pages 624-627, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7451:d:10.1038_nature12146
    DOI: 10.1038/nature12146
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    Cited by:

    1. Manisha Jalan & Aman Sharma & Xin Pei & Nils Weinhold & Erika S. Buechelmaier & Yingjie Zhu & Sana Ahmed-Seghir & Abhirami Ratnakumar & Melody Bona & Niamh McDermott & Joan Gomez-Aguilar & Kyrie S. An, 2024. "RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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