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Crystal structure of the integral membrane diacylglycerol kinase

Author

Listed:
  • Dianfan Li

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

  • Joseph A. Lyons

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

  • Valerie E. Pye

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Present addresses: Clare Hall Laboratories, Cancer Research UK, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK (V.E.P.); Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria VIC 3168, Australia (D.A.); The Matrix Biology Group, Kennedy Institute of Rheumatology, University of Oxford, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK (C.D.).)

  • Lutz Vogeley

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

  • David Aragão

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Present addresses: Clare Hall Laboratories, Cancer Research UK, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK (V.E.P.); Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria VIC 3168, Australia (D.A.); The Matrix Biology Group, Kennedy Institute of Rheumatology, University of Oxford, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK (C.D.).)

  • Colin P. Kenyon

    (CSIR, Biosciences, Meiring-Naude Road, Pretoria 0184, Gauteng, South Africa)

  • Syed T. A. Shah

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

  • Christine Doherty

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland
    Present addresses: Clare Hall Laboratories, Cancer Research UK, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK (V.E.P.); Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria VIC 3168, Australia (D.A.); The Matrix Biology Group, Kennedy Institute of Rheumatology, University of Oxford, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK (C.D.).)

  • Margaret Aherne

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

  • Martin Caffrey

    (School of Biochemistry and Immunology & School of Medicine, Trinity College Dublin, Dublin 2, Ireland)

Abstract

This study presents the crystal structures of three functional forms of diacylglycerol kinase, an integral membrane protein that catalyses a crucial step in oligosaccharide and lipopolysaccharide synthesis and assembly; these X-ray structures are markedly different from the only other structure available for this unique kinase that was solved using solution NMR.

Suggested Citation

  • Dianfan Li & Joseph A. Lyons & Valerie E. Pye & Lutz Vogeley & David Aragão & Colin P. Kenyon & Syed T. A. Shah & Christine Doherty & Margaret Aherne & Martin Caffrey, 2013. "Crystal structure of the integral membrane diacylglycerol kinase," Nature, Nature, vol. 497(7450), pages 521-524, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12179
    DOI: 10.1038/nature12179
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    Cited by:

    1. Guangjian Li & Hui Liang & Ruichen Gao & Ling Qin & Pei Xu & Mingtao Huang & Min-Hua Zong & Yufei Cao & Wen-Yong Lou, 2024. "Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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