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Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

Author

Listed:
  • Unnur Styrkarsdottir

    (deCODE Genetics/Amgen)

  • Gudmar Thorleifsson

    (deCODE Genetics/Amgen)

  • Patrick Sulem

    (deCODE Genetics/Amgen)

  • Daniel F. Gudbjartsson

    (deCODE Genetics/Amgen)

  • Asgeir Sigurdsson

    (deCODE Genetics/Amgen)

  • Aslaug Jonasdottir

    (deCODE Genetics/Amgen)

  • Adalbjorg Jonasdottir

    (deCODE Genetics/Amgen)

  • Asmundur Oddsson

    (deCODE Genetics/Amgen
    Karolinska Institutet)

  • Agnar Helgason

    (deCODE Genetics/Amgen)

  • Olafur T. Magnusson

    (deCODE Genetics/Amgen)

  • G. Bragi Walters

    (deCODE Genetics/Amgen)

  • Michael L. Frigge

    (deCODE Genetics/Amgen)

  • Hafdis T. Helgadottir

    (deCODE Genetics/Amgen)

  • Hrefna Johannsdottir

    (deCODE Genetics/Amgen)

  • Kristin Bergsteinsdottir

    (University of Iceland, Biomedical Center)

  • Margret H. Ogmundsdottir

    (University of Iceland, Biomedical Center)

  • Jacqueline R. Center

    (Garvan Institute of Medical Research
    St Vincent’s Hospital
    University of New South Wales (UNSW))

  • Tuan V. Nguyen

    (Garvan Institute of Medical Research
    University of New South Wales (UNSW))

  • John A. Eisman

    (Garvan Institute of Medical Research
    St Vincent’s Hospital
    University of New South Wales (UNSW)
    University of Notre Dame Australia (UNDA))

  • Claus Christiansen

    (Center for Clinical and Basic Research (CCBR))

  • Erikur Steingrimsson

    (University of Iceland, Biomedical Center)

  • Jon G. Jonasson

    (Landspitali, The National University Hospital of Iceland
    Faculty of Medicine, University of Iceland
    Icelandic Cancer Registry)

  • Laufey Tryggvadottir

    (Faculty of Medicine, University of Iceland
    Icelandic Cancer Registry)

  • Gudmundur I. Eyjolfsson

    (Laboratory in Mjodd (RAM), Icelandic Medical Center (Laeknasetrid))

  • Asgeir Theodors

    (Landspitali, The National University Hospital of Iceland)

  • Thorvaldur Jonsson

    (Faculty of Medicine, University of Iceland
    Landspitali, The National University Hospital of Iceland)

  • Thorvaldur Ingvarsson

    (Akureyri Hospital
    Institution of Health Science, University of Akureyri)

  • Isleifur Olafsson

    (Landspitali, The National University Hospital of Iceland)

  • Thorunn Rafnar

    (deCODE Genetics/Amgen)

  • Augustine Kong

    (deCODE Genetics/Amgen)

  • Gunnar Sigurdsson

    (Faculty of Medicine, University of Iceland
    Landspitali, The National University Hospital of Iceland)

  • Gisli Masson

    (deCODE Genetics/Amgen)

  • Unnur Thorsteinsdottir

    (deCODE Genetics/Amgen
    Faculty of Medicine, University of Iceland)

  • Kari Stefansson

    (deCODE Genetics/Amgen
    Faculty of Medicine, University of Iceland)

Abstract

Analysis of whole-genome sequence data of Icelandic individuals has revealed a rare nonsense mutation within the LGR4 gene that is strongly associated with, among other things, low bone mineral density, late onset of menarche, and increased risk of biliary tract cancer.

Suggested Citation

  • Unnur Styrkarsdottir & Gudmar Thorleifsson & Patrick Sulem & Daniel F. Gudbjartsson & Asgeir Sigurdsson & Aslaug Jonasdottir & Adalbjorg Jonasdottir & Asmundur Oddsson & Agnar Helgason & Olafur T. Mag, 2013. "Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits," Nature, Nature, vol. 497(7450), pages 517-520, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12124
    DOI: 10.1038/nature12124
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    Cited by:

    1. Olga Kubrak & Anne F. Jørgensen & Takashi Koyama & Mette Lassen & Stanislav Nagy & Jacob Hald & Gianluca Mazzoni & Dennis Madsen & Jacob B. Hansen & Martin Røssel Larsen & Michael J. Texada & Jakob L., 2024. "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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