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Reconfiguration of the proteasome during chaperone-mediated assembly

Author

Listed:
  • Soyeon Park

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    MCD Biology, University of Colorado Boulder)

  • Xueming Li

    (The W.M. Keck Advanced Microscopy Laboratory, University of California San Francisco, 600 16th Street, San Francisco, California 94158, USA)

  • Ho Min Kim

    (The W.M. Keck Advanced Microscopy Laboratory, University of California San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Present address: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.)

  • Chingakham Ranjit Singh

    (Kansas State University, 338 Ackert Hall, Manhattan, Kansas 66506, USA)

  • Geng Tian

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Martin A. Hoyt

    (University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA)

  • Scott Lovell

    (Protein Structure Laboratory, Del Shankel Structural Biology Center, University of Kansas)

  • Kevin P. Battaile

    (IMCA-CAT Hauptman-Woodward Medical Research Institute, 9700 South Cass Avenue, Building 435A, Argonne, Illinois 60439, USA)

  • Michal Zolkiewski

    (Kansas State University, 176 Chalmers Hall, Manhattan, Kansas 66506, USA)

  • Philip Coffino

    (University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA)

  • Jeroen Roelofs

    (Kansas State University, 338 Ackert Hall, Manhattan, Kansas 66506, USA)

  • Yifan Cheng

    (The W.M. Keck Advanced Microscopy Laboratory, University of California San Francisco, 600 16th Street, San Francisco, California 94158, USA)

  • Daniel Finley

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

The proteasome degrades ubiquitin-conjugated substrates; here, structural and functional insights from studies in yeast reveal that it is reconfigured during chaperone-mediated assembly.

Suggested Citation

  • Soyeon Park & Xueming Li & Ho Min Kim & Chingakham Ranjit Singh & Geng Tian & Martin A. Hoyt & Scott Lovell & Kevin P. Battaile & Michal Zolkiewski & Philip Coffino & Jeroen Roelofs & Yifan Cheng & Da, 2013. "Reconfiguration of the proteasome during chaperone-mediated assembly," Nature, Nature, vol. 497(7450), pages 512-516, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12123
    DOI: 10.1038/nature12123
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