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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Author

Listed:
  • Kari Ann Shirey

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Wendy Lai

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Alison J. Scott

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Michael Lipsky

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Pragnesh Mistry

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Lioubov M. Pletneva

    (Sigmovir Biosystems, Inc.)

  • Christopher L. Karp

    (Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Present addresses: The Bill & Melinda Gates Foundation, Seattle, Washington 98109, USA (C.L.K.); Taisho Pharmaceutical R&D, Inc., Morristown, New Jersey 07960, USA (D.P.R.).)

  • Jaclyn McAlees

    (Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA)

  • Theresa L. Gioannini

    (The Inflammation Program, University of Iowa
    Department of Veterans Affairs Medical Center)

  • Jerrold Weiss

    (The Inflammation Program, University of Iowa)

  • Wilbur H. Chen

    (Center for Vaccine Development, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Robert K. Ernst

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

  • Daniel P. Rossignol

    (Eisai, Inc.
    Present addresses: The Bill & Melinda Gates Foundation, Seattle, Washington 98109, USA (C.L.K.); Taisho Pharmaceutical R&D, Inc., Morristown, New Jersey 07960, USA (D.P.R.).)

  • Fabian Gusovsky

    (Eisai, Inc.)

  • Jorge C. G. Blanco

    (Sigmovir Biosystems, Inc.)

  • Stefanie N. Vogel

    (University of Maryland, Baltimore, Baltimore, Maryland 21201, USA)

Abstract

TLR4 stimulation is known to contribute to acute lung injury after administration of inactivated influenza virus; here, the synthetic TLR4 antagonist Eritoran is shown to protect mice from death after infection with a lethal dose of the virus.

Suggested Citation

  • Kari Ann Shirey & Wendy Lai & Alison J. Scott & Michael Lipsky & Pragnesh Mistry & Lioubov M. Pletneva & Christopher L. Karp & Jaclyn McAlees & Theresa L. Gioannini & Jerrold Weiss & Wilbur H. Chen & , 2013. "The TLR4 antagonist Eritoran protects mice from lethal influenza infection," Nature, Nature, vol. 497(7450), pages 498-502, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12118
    DOI: 10.1038/nature12118
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