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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Author

Listed:
  • Jia Shen

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences at Houston)

  • Weiya Xia

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Yekaterina B. Khotskaya

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Longfei Huo

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Kotaro Nakanishi

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Seung-Oe Lim

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Yi Du

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences at Houston)

  • Yan Wang

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Wei-Chao Chang

    (Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University
    Genomics Research Center, Academia Sinica)

  • Chung-Hsuan Chen

    (Genomics Research Center, Academia Sinica)

  • Jennifer L. Hsu

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University
    Asia University)

  • Yun Wu

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Yung Carmen Lam

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Brian P. James

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Xiuping Liu

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Chang-Gong Liu

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Mien-Chie Hung

    (The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences at Houston
    Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University
    Asia University)

Abstract

Epidermal growth factor receptor, the product of a human oncogene, suppresses the maturation of specific tumour-suppressor-like microRNAs in response to hypoxic stress through phosphorylation of argonaute 2.

Suggested Citation

  • Jia Shen & Weiya Xia & Yekaterina B. Khotskaya & Longfei Huo & Kotaro Nakanishi & Seung-Oe Lim & Yi Du & Yan Wang & Wei-Chao Chang & Chung-Hsuan Chen & Jennifer L. Hsu & Yun Wu & Yung Carmen Lam & Bri, 2013. "EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2," Nature, Nature, vol. 497(7449), pages 383-387, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7449:d:10.1038_nature12080
    DOI: 10.1038/nature12080
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