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Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

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  • Amelia E. Hochreiter-Hufford

    (Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Beirne B. Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA)

  • Chang Sup Lee

    (Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Beirne B. Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA)

  • Jason M. Kinchen

    (Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Beirne B. Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA)

  • Jennifer D. Sokolowski

    (Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Sanja Arandjelovic

    (Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Beirne B. Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA)

  • Jarrod A. Call

    (Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Alexander L. Klibanov

    (Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Zhen Yan

    (Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • James W. Mandell

    (Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Kodi S. Ravichandran

    (Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Beirne B. Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA)

Abstract

The apoptotic event of phosphatidylserine exposure and its recognition by the receptor BAI1 has an unexpected new role as a signal enhancing mouse myoblast fusion, an insight with relevance to some congenital muscle diseases and muscle injury treatments.

Suggested Citation

  • Amelia E. Hochreiter-Hufford & Chang Sup Lee & Jason M. Kinchen & Jennifer D. Sokolowski & Sanja Arandjelovic & Jarrod A. Call & Alexander L. Klibanov & Zhen Yan & James W. Mandell & Kodi S. Ravichand, 2013. "Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion," Nature, Nature, vol. 497(7448), pages 263-267, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12135
    DOI: 10.1038/nature12135
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    Cited by:

    1. Viviane Tran & Sarah Nahlé & Amélie Robert & Inès Desanlis & Ryan Killoran & Sophie Ehresmann & Marie-Pier Thibault & David Barford & Kodi S. Ravichandran & Martin Sauvageau & Matthew J. Smith & Marie, 2022. "Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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