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M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

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  • Noushine Mossadegh-Keller

    (Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Institut National de la Santé et de la Recherche Médicale, U1104, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Centre National de la Recherche Scientifique, UMR7280, Campus de Luminy)

  • Sandrine Sarrazin

    (Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Institut National de la Santé et de la Recherche Médicale, U1104, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Centre National de la Recherche Scientifique, UMR7280, Campus de Luminy)

  • Prashanth K. Kandalla

    (Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Institut National de la Santé et de la Recherche Médicale, U1104, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Centre National de la Recherche Scientifique, UMR7280, Campus de Luminy)

  • Leon Espinosa

    (Laboratoire de Chimie Bactérienne, Centre National de la Recherche Scientifique, UMR 7283, 31 Chemin Joseph Aiguier, 13009 Marseille, France)

  • E. Richard Stanley

    (Albert Einstein College of Medicine)

  • Stephen L. Nutt

    (Walter and Eliza Hall Institute, 1G Royal Parade)

  • Jordan Moore

    (Fluidigm Corporation)

  • Michael H. Sieweke

    (Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Institut National de la Santé et de la Recherche Médicale, U1104, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Centre National de la Recherche Scientifique, UMR7280, Campus de Luminy
    Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13125 Berlin, Germany)

Abstract

M-CSF, a myeloid cytokine released during infection and inflammation, instructs myeloid lineage fate in single haematopoietic stem cells by directly inducing PU.1, a known myeloid lineage master regulator; this shows that specific cytokines can act directly on haematopoietic stem cells to instruct a change of cell identity.

Suggested Citation

  • Noushine Mossadegh-Keller & Sandrine Sarrazin & Prashanth K. Kandalla & Leon Espinosa & E. Richard Stanley & Stephen L. Nutt & Jordan Moore & Michael H. Sieweke, 2013. "M-CSF instructs myeloid lineage fate in single haematopoietic stem cells," Nature, Nature, vol. 497(7448), pages 239-243, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12026
    DOI: 10.1038/nature12026
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    Cited by:

    1. Jacqueline Feyen & Zhen Ping & Lanpeng Chen & Claire Dijk & Tim V. D. Tienhoven & Paulina M. H. Strien & Remco M. Hoogenboezem & Michiel J. W. Wevers & Mathijs A. Sanders & Ivo P. Touw & Marc H. G. P., 2022. "Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Kiyoka Saito & Mark Garde & Terumasa Umemoto & Natsumi Miharada & Julia Sjöberg & Valgardur Sigurdsson & Haruki Shirozu & Shunsuke Kamei & Visnja Radulovic & Mitsuyoshi Suzuki & Satoshi Nakano & Stefa, 2024. "Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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